Oxycodone vs Hydrocodone

Oxycodone vs Hydrocodone

Oxycodone vs Hydrocodone are both opioid drugs commonly used for pain relief in the USA. The two drugs are so similar that there are no specific symptoms that will reliably differentiate the effects of Hydrocodone from the effects of Oxycodone. Below is what you need to know about the two drugs and the differences between them.

What is Hydrocodone?

Hydrocodone is a generic opioid drug used to relieve severe pain. It is typically used by patients who need pain relief for an extended period. The brand names of this drug include Zohydro ER and Hysingla ER, both extended-release drugs and long-acting forms of Hydrocodone. Several other medications contain Hydrocodone. It is a controlled drug, a Schedule II Controlled Substance in the USA.

Commonly Hydrocodone is dispensed as the combination of ibuprofen/ hydrocodone and hydrocodone/ acetaminophen for pain severe enough to need an opioid. This drug is also formulated in combination with homatropine methyl bromide for cough suppression. This drug is also available by itself in a long-acting form to relieve the severe pain of prolonged duration. You can buy Hydrocodone online from our reliable pharmacy site, as we give our users the option to order medicines anytime from the comfort of their homes. We also provide guaranteed overnight delivery of the drugs.

How does it work for pain relief?

Hydrocodone is a narcotic pain drug that binds to the opioid receptors in the CNS and alters the way pain is perceived. Once in the body, this drug activates the mu opiate receptor to block the feeling of pain. This drug reduces the overall activity of the CNS, which includes blood pressure, heart rate, and respiration. This slowing of the CNS is why patients must imperatively follow dosing instructions.

What is Oxycodone?

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Oxycodone is a short-acting opioid drug. Oxycodone comes in an extended-release and immediate-release tablet formulation. Doctors commonly prescribe this drug for treating and managing pain. Oxycodone is short-acting and relieves pain for an average of 4 to 6 hours, so you need to take it 4 to 6 times a day to provide pain relief for the whole day. People usually buy Oxycodone online for acute pain following a trauma or surgery.

How does it act to relieve pain?

Opioid drugs such as Oxycodone attach to proteins known as opioid receptors on nerve cells in your brain, spinal cord, gut, and other parts of the body. When this happens, this opioid drug blocks pain messages sent from the body through the spinal cord to the brain. You may order Oxycodone online from our site because we allow a return and guaranteed refund if you face any issues with our product.

What are the medical uses of Oxycodone?

People often use Oxycodone to relieve moderate-to-severe pain. This drug is usually given for acute pain, like that, following surgery or trauma. It would help if you took higher dosages of this drug for increased pain relief. People use Oxycodone extended-release tablets and capsules to control severe pain. It is commonly used in patients expected to need pain medicine around the clock for a considerable amount of time and can not be treated with other medicines.

People with acute pain, such as following surgery or trauma, often prefer Oxycodone, as Oxycodone works quickly. It is also available in combination with other pain-relieving drugs, such as ibuprofen or acetaminophen. Oxycodone can be used to treat severe pain, uncontrolled by alternative, non-opioid analgesic drugs, like that caused by:

  • Certain medical conditions ( like shingles )
  • Injuries
  • Break-through pain that happens during regular dosing of Oxycontin
  • Trauma.

Oxycodone vs. Hydrocodone

As discussed above, there are no significant differences between Oxycodone and Hydrocodone. Both are effective pain reliever drugs.

  • The only difference could be that Hydrocodone has an average half-life of about 3.8 hours in a healthy adult. In contrast, the mean apparent elimination half-life of Oxycodone is around 4.5 hours.
  • Immediate-release Oxycodone tablets are available in 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg, while capsules are 5 mg strength. Oral solution is available in 5 mg / 5 ml strength and oral concentrate is available in 100 mg / 5 mL strength. While, Hydrocodone 5 mg, 2.5 mg, 10 mg, and 7.5 mg are mostly available in combination with other drugs.
  • The brand names for Hydrocodone are Zohydro ER and Hysingla ER. In contrast, the brand names for Oxycodone are OxyContin, and Roxicodone, among others.

Which is stronger, Oxycodone vs Hydrocodone?

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According to studies, the combination of Oxycodone and Acetaminophen is about 1.5 times more potent than Hydrocodone with Acetaminophen when you take them at equal doses for pain relief. Both Oxycodone and Hydrocodone are effective at easing chronic and acute pain. They both cause pretty similar side effects. The differences between Hydrocodone and Oxycodone are minimal.

Thus, the best way to pick which drug is right for you is by having a conversation with the doctor. Based on your personal medical history, the doctor will weigh the pros and cons of the two drugs. Some medical professionals and researchers find that Hydrocodone is less potent than Oxycodone.

How should I take Hydrocodone and Oxycodone?

One can take Hydrocodone and Oxycodone with or without food, and patients usually take these drugs every four to six hours. In case you experience nausea, you can take the drugs with food. You may discuss with your doctor other techniques to control nausea. It would be best to swallow whole Hydrocodone or Oxycodone tablets and not crush, chew, break, or dissolve them, leading to an overdose by releasing all of the drugs at once. Take only a single Hydrocodone or Oxycodone tablet at a time to ensure you do not get choked if your prescribed dosage is for more than one tablet.

For adults over 18 years: It would be best if you took Hydrocodone¬†or Oxycodone tablets at an interval of 4 to 6 hours. The dosage depends upon the severity of the pain. It also depends on the patient’s previous history of the requirements of analgesics. Usually, the minimum effective dosage for pain relief must be selected. With the increased severity of pain, the dose of Hydrocodone or Oxycodone tablets must be increased, using their different tablet strengths to achieve pain relief in patients.

Side effects of Hydrocodone vs. that of Oxycodone

Oxycodone and Hydrocodone are chemically pretty similar, and both belong to the opioid class of drugs. It means that the effects of an Oxycodone high are very similar to those of a Hydrocodone high. Some possible Oxycodone side effects are:

  • Nausea and vomiting
  • Dry mouth, hives, and changes in heartbeat
  • Trouble breathing or swallowing
  • Swelling of the face, lips, and tongue
  • Stomach pain, tiredness, headache, back pain, muscle tightening, and ringing in the ears
  • Difficult, frequent, or painful urination
  • Difficulty falling asleep or staying asleep.
  • Uncontrollable shaking of one part of your body
  • Foot, leg, or ankle swelling

The Hydrocodone side effects are the same as those of Oxycodone, as mentioned above.


Oxycodone and Hydrocodone are effective painkiller drugs. They are used to treat moderate to severe pain. They are quite similar, and there are not many differences between them

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